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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

Updated: May 27, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Epigenomic insights into common disease.

Kate Revill1, Benjamin Tycko

  • 1Cold Spring Harbor Laboratory, New York, NY 11794, USA. revill@cshl.edu.

Genome Medicine
|November 17, 2011
PubMed
Summary

This conference explored epigenomics, the study of how environmental factors affect gene activity. Key discussions focused on epigenomic insights into common diseases and future research directions.

Area of Science:

  • Genetics and Genomics
  • Molecular Biology
  • Disease Research

Background:

  • The conference convened experts to discuss the rapidly evolving field of epigenomics.
  • Focus was placed on understanding the role of epigenetics in common human diseases.

Purpose of the Study:

  • To summarize key findings and discussions from the Wellcome Trust Scientific Conference on Epigenomics of Common Diseases.
  • To highlight emerging trends and future research priorities in the field.

Main Methods:

  • The report is based on presentations and discussions from a scientific conference.
  • Expert insights and consensus on epigenomic research were gathered.

Main Results:

  • Epigenomic mechanisms are increasingly recognized as crucial in the pathogenesis of common diseases.

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

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  • Advances in technology are enabling large-scale epigenomic studies.
  • Translational applications of epigenomic findings are a growing area of interest.
  • Conclusions:

    • Continued investment in epigenomics research is vital for understanding and treating common diseases.
    • Interdisciplinary collaboration is essential for progress in the field.
    • Future research should focus on integrating epigenomic data with other biological information.