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Updated: May 27, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
[A spontaneously resolving T-cell lymphoma]
Elisabeth R Mutsaers1, Rein Willemze, Michelle M van Rossum
1Universitair Medisch Centrum St Radboud, afd. Dermatologie, Nijmegen, the Netherlands. e.mutsaers@derma.umcn.nl
Background:
Primary cutaneous CD30+ anaplastic large-cell lymphoma is a rare form of non-Hodgkin's lymphoma, which is restricted to the skin.
Case Description:
A 50-year-old man presented with an asymptomatic tumorous area in the groin that had appeared within the previous week, and a longer history of a transient red, flaking area in the popliteal space. Histopathological findings were consistent with CD30+ anaplastic large-cell lymphoma. Staging demonstrated no extracutanous spread. The skin lesions disappeared without treatment within 3 months.
Conclusion:
Primary cutaneous CD30+ anaplastic large-cell lymphoma is a rare condition. It has a histopathological picture of a diffuse proliferation of large atypical anaplastic cells, suggesting an unfavourable disease course. However, this condition is characterised by a indolent course and favourable prognosis since spontaneous complete regression can occur.
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