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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
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Related Experiment Video

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An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
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Published on: January 27, 2010

Predictors for persistent neuropathic pain--a Delphi survey.

Sabine Boogaard1, Martijn W Heymans, Jacob Patijn

  • 1Department of Anesthesiology, VU University Medical Center, Amsterdam, The Netherlands. s.boogaard@vumc.nl

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|November 17, 2011
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Summary

Psychological factors like depression and pain catastrophizing, alongside sensory disturbances, are key predictors for the persistence of neuropathic pain. Identifying these factors can help prevent chronic pain and improve patient care.

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Last Updated: May 27, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
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Published on: January 27, 2010

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Area of Science:

  • Pain Research
  • Clinical Psychology
  • Neurology

Background:

  • Chronic neuropathic pain significantly impacts patients' quality of life.
  • Identifying predictors of pain persistence is crucial for effective management and prevention.
  • Early identification aids in improving neuropathic pain care strategies.

Purpose of the Study:

  • To identify potential predictors associated with the persistence of neuropathic pain.
  • To establish a foundation for developing a clinical prediction rule for chronic neuropathic pain.

Main Methods:

  • A two-round Delphi study involving 17 neuropathic pain experts.
  • Expert selection based on citation index and IASP membership.
  • Predictors evaluated using a 0-10 scale; importance defined by median score ≥ 7 and IQR ≤ 3.

Main Results:

  • 12 key predictors identified across categories: patient characteristics, environmental factors, functions & structure, and participation.
  • Depression and pain catastrophizing emerged as the most significant predictors.
  • Allodynia and duration of complaints were also identified as important predictors within functions & structure.

Conclusions:

  • Psychological factors and sensory disturbances are critical predictors of neuropathic pain persistence.
  • Activity-related factors and prior alternative treatments were deemed less important.
  • The identified predictors can inform the development of a clinical prediction rule for chronic neuropathic pain.