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[Antimicrobial susceptibility of helicobacter pylori to levofloxacin determined in a miniwell format and disk
Humberto Mochizuki Tamayo1, Adrián Pedro Noriega Aldave
1Universidad Peruana Cayetano Heredia, Lima, Perú.
Objectives:
To determine the Minimum inhibitory concentration (MIC) of Levofloxacin against HELICOBACTER PYLORI (HP).
Materials And Methods:
95 HP Peruvian strains were evaluated in Agar dilution and Disk diffusion tests, as well as the Pearson Coefficient (r) and the inoculum's effect.
Results:
36.9% (35 of 95) were resistant (MIC>1 μg/ml) to Levofloxacin. MIC₉₀ was 16 ug/ml (CI:90%). MIC of Levofloxacin did not change at different inoculum concentrations. r: -0.733 (p<0.001).
Conclusions:
The proportion of HP Levofloxacin resistant strains in Peru is higher than in developed countries. Periodic testing of antibiotic susceptibility is warranted to select the most accurate therapies.
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