[Topical therapy of ulcerative colitis].

Area of Science:

• Gastroenterology
• Pharmacology

Context:

• Mild to moderate-active left-sided ulcerative colitis requires effective treatment options.
• Systemic therapies for ulcerative colitis can have significant side effects.
• Topical rectal therapies offer an alternative for distal colitis management.

Purpose:

• To evaluate the efficacy and patient compliance of new topical preparations for left-sided ulcerative colitis.
• To compare topical rectal therapy with systemic therapy for mild to moderate left-sided colitis.
• To highlight the advantages of topical therapy in ulcerative colitis treatment guidelines.

Summary:

• New topical preparations for left-sided ulcerative colitis (ulcerative colitis ulcerosa) enhance therapeutic optimization.
• Rectal administration of steroids and 5-aminosalicylic acid (5-ASA) demonstrates superior efficacy and reduced side effects compared to systemic treatments in mild to moderate left-sided colitis.
• Patient compliance with rectal therapy is often underestimated and improves with education on its benefits.
• Topical rectal drug application is effective for maintaining remission in distal ulcerative colitis.
• Current therapy guidelines increasingly recommend topical treatments for distal colitis due to demonstrated clinical advantages.

Impact:

• Optimized treatment strategies for left-sided ulcerative colitis.
• Improved patient outcomes through enhanced efficacy and reduced side effects of topical therapies.
• Increased adoption of topical rectal therapies in clinical practice for ulcerative colitis management.