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Updated: May 27, 2026
13:08
Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
Data from extension trials: denosumab and zoledronic acid
1David Geffen School of Medicine, Division of Rheumatology, UCLA, 18102 Irvine Blvd Suite 104, Tustin, CA 92780, USA. rkdmail@sbcglobal.net
Current Osteoporosis Reports
|November 17, 2011
Summary
Osteoporosis treatments are evolving beyond oral bisphosphonates. New parenteral therapies like denosumab and zoledronic acid offer alternatives, with long-term data crucial for managing fracture risk.
Area of Science:
- Gerontology
- Orthopedics
- Pharmacology
Background:
- Osteoporosis and associated fractures represent a significant public health concern, leading to increased morbidity and mortality.
- Aging is a primary risk factor for osteoporosis, yet awareness of available fracture-reducing therapies remains low.
- Traditional oral bisphosphonates for osteoporosis have administration challenges, prompting the need for alternative treatments.
Purpose of the Study:
- To review long-term efficacy and safety data for newer osteoporosis treatments.
- To compare extension trial data for denosumab and zoledronic acid.
Main Methods:
- Review of extension trial data for denosumab.
- Review of extension trial data for zoledronic acid.
Main Results:
- Long-term data collection is essential for osteoporosis therapies due to extended treatment durations.
- Parenteral antiresorptive drugs, denosumab and zoledronic acid, have been approved and require ongoing safety and efficacy evaluation.
Conclusions:
- Continued evaluation of long-term data for denosumab and zoledronic acid is necessary.
- The development of parenteral antiresorptive drugs addresses limitations of oral bisphosphonates in osteoporosis management.
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