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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Wanggui Yang1, Yi Wong, Olivia T W Ng

  • 1Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China.

Angewandte Chemie (International Ed. in English)
|November 17, 2011
PubMed
Abstract

No abstract available in PubMed .

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...