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Primary hepatic diffuse large B cell lymphoma: A case report: Primary hepatic diffuse large B cell lymphoma
Yuan-Ji Ma1, En-Qiang Chen, Xue-Bing Chen
1Center of Infectious Diseases, West China Hospital of Sichuan University, Sichuan Province, China.
Hepatitis Monthly
|November 17, 2011
Summary
This report details a rare case of primary hepatic diffuse large B cell lymphoma in a 67-year-old man. Despite initial favorable response to chemotherapy, the patient succumbed to complications.
Area of Science:
- Hepatology
- Oncology
- Pathology
Background:
- Primary hepatic diffuse large B cell lymphoma (DLBCL) is an exceptionally rare malignancy.
- DLBCL typically affects lymph nodes, making intrahepatic presentation unusual.
Observation:
- A 67-year-old male presented with abdominal pain, liver dysfunction, and elevated lactate dehydrogenase.
- Imaging revealed diffuse nodular intrahepatic space-occupying lesions with normal tumor markers (AFP, CEA).
Findings:
- Percutaneous liver biopsy confirmed primary hepatic DLBCL, as clinical presentation mimicked other liver diseases.
- Treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) yielded a positive initial response.
Implications:
- This case highlights the diagnostic challenges of rare intrahepatic DLBCL.
- Management requires tailored chemotherapy, and vigilance for severe treatment complications is crucial.
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