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Updated: May 27, 2026
09:50
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Flavonoids as acetylcholinesterase inhibitors
1Department of Pharmacy and Pharmaceutical Technology, University of Navarra, Irunlarrea s/n, 31008 Pamplona, Navarra, Spain. iuriartep@unav.es
Current Medicinal Chemistry
|November 18, 2011
Summary
Flavonoids show promise for Alzheimer's disease (AD) treatment by inhibiting acetylcholinesterase (AChE) and offering antioxidant benefits. This review details 128 natural and synthetic flavonoids as potential multipotent AD therapies.
Area of Science:
- Pharmacology
- Neuroscience
- Natural Product Chemistry
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
- Current symptomatic treatments primarily involve acetylcholinesterase inhibitors (AChEI).
- Flavonoids are natural compounds with known antioxidant properties.
Purpose of the Study:
- To review natural and synthetic flavonoids with acetylcholinesterase (AChE) inhibitory activity.
- To explore the potential of flavonoids as multipotent therapeutic agents for AD.
- To classify identified flavonoids based on their chemical structures.
Main Methods:
- Literature review of scientific articles and databases.
- Identification and compilation of flavonoids exhibiting AChE inhibitory effects.
- Classification of flavonoids according to their chemical structures.
- Summary of 64 relevant references.
Main Results:
- Identified 128 flavonoids with potential AChE inhibitory activity.
- Highlighted the dual action of flavonoids: AChE inhibition and antioxidant effects.
- Demonstrated the structural diversity of flavonoid AChE inhibitors.
Conclusions:
- Flavonoids represent a promising class of compounds for Alzheimer's disease (AD) therapy.
- Their ability to inhibit acetylcholinesterase (AChE) and provide antioxidant support makes them multipotent candidates.
- Further research into specific flavonoids could lead to novel AD treatments.
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