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Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants
Published on: December 1, 2010
Nanostructures for drug delivery to the brain
L Martin-Banderas1, M A Holgado, J L Venero
1Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, c/ Prof. García González n°2, 41012 Seville, Spain. luciamartin@us.es
Current Medicinal Chemistry
|November 18, 2011
Summary
This review covers drug delivery methods for the central nervous system (CNS), focusing on overcoming the blood-brain barrier (BBB). Polymeric nanoparticles show promise for treating neurological disorders like brain tumors and neurodegenerative diseases.
Area of Science:
- Neuroscience
- Pharmacology
- Biotechnology
Background:
- Neurological disorders are often linked to blood-brain barrier (BBB) dysfunction.
- Effective drug delivery to the central nervous system (CNS) is a significant challenge due to the BBB.
- Existing treatments face limitations in penetrating the BBB.
Purpose of the Study:
- To review current strategies for delivering drugs to the CNS.
- To highlight the role of the BBB and associated pathologies.
- To emphasize advanced delivery systems, particularly nanocarriers.
Main Methods:
- Literature review of drug delivery approaches for CNS disorders.
- Analysis of BBB disruption, prodrugs, and molecular Trojan horse strategies.
- Focus on nanocarriers, specifically polymeric nanoparticles, for targeted brain delivery.
Main Results:
- Various methods exist to circumvent the BBB for drug delivery.
- Polymeric nanoparticles are identified as a highly promising strategy for CNS drug targeting.
- These advanced methods offer potential for treating previously intractable conditions.
Conclusions:
- Nanoparticle-based drug delivery represents a significant advancement for CNS therapeutics.
- Targeted delivery to the brain can address brain tumors and neurodegenerative diseases.
- Emerging technologies from pharmaceutical companies are expanding treatment options.
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