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Related Experiment Video

Updated: May 27, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Insights into immunophilin structure and function.

C Lücke1, M Weiwad

  • 1Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, 06120 Halle (Saale), Germany. luecke@enzyme-halle.mpg.de

Current Medicinal Chemistry
|November 18, 2011
PubMed
Summary
This summary is machine-generated.

Immunophilins are proteins that modulate immune responses and catalyze protein folding. This review details their structures, active sites, and biological functions, aiding research in immunology and protein science.

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Area of Science:

  • Biochemistry
  • Immunology
  • Structural Biology

Background:

  • Immunophilins are proteins involved in immune response modulation when used with immunosuppressive drugs.
  • Their primary natural role is catalyzing cis/trans isomerization of peptidyl-prolýl bonds in proteins.

Purpose of the Study:

  • To review available immunophilin structure coordinates from the RCSB Protein Data Bank.
  • To identify key active-site factors influencing immunophilin catalytic and immunological functions.
  • To provide an overview of the biologically relevant functions of various immunophilin members.

Main Methods:

  • Literature review of immunophilin structures.
  • Analysis of protein data bank (RCSB PDB) coordinates.
  • Identification of key active-site residues and structural features.

Main Results:

  • Compilation of all currently available immunophilin structure coordinates.
  • Highlighting of critical active-site elements responsible for catalytic and immunological activities.
  • Summary of diverse biological roles across different immunophilin family members.

Conclusions:

  • Understanding immunophilin structures and active sites is crucial for elucidating their dual roles.
  • Structural data provides insights into the mechanisms of immunosuppression and protein folding.
  • This review serves as a comprehensive resource for researchers in related fields.