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Immunophilins and cardiovascular complications.
E Calderón-Sánchez1, M Rodriguez-Moyano, T Smani
1Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío, Grupo de Fisiopatología Cardiovascular, Lab 113, Avenida Manuel Siurot s/n, Sevilla 41013, Spain.
Current Medicinal Chemistry
|November 18, 2011
Summary
Immunophilins are crucial proteins regulating cellular functions and are implicated in cardiovascular diseases. This review highlights recent research on their roles in cardiovascular disease mechanisms.
Area of Science:
- Molecular Biology
- Cardiovascular Research
- Immunology
Background:
- Immunophilins are conserved proteins with peptidyl-prolyl isomerase activity.
- They are classified by drug-binding properties: Cyclophilins (CsA), FKBP (FK506, rapamycin), FCBPs (CsA, FK506).
- Expressed in various tissues, they regulate diverse cellular functions like calcium signaling and gene transcription.
Purpose of the Study:
- To review recent studies on immunophilins.
- To focus on their roles in cardiovascular disease mechanisms.
Main Methods:
- Literature review of recent studies on immunophilins.
- Analysis of immunophilin interactions with cardiovascular proteins.
Main Results:
- Immunophilins play key roles in the cardiovascular system.
- They associate with proteins like ryanodine receptors, IP3 receptors, calcineurin, and MPTP.
- Implicated in cardiovascular diseases such as stenosis, atherosclerosis, heart failure, and arrhythmias.
Conclusions:
- Immunophilins are vital in cardiovascular function and disease.
- Further research into their mechanisms is warranted for therapeutic development.
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