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Related Experiment Video

Updated: May 27, 2026

The Immediate Partial Removal of Cumulus-Oocyte Complexes: A Refined Approach for Rapid Observation of In Vitro Fertilization

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Published on: October 18, 2024

Intracytoplasmic sperm injection in partial globozoospermia.

Anika H D M Dam¹, Adriënne J E Pijnenburg, Jan C M Hendriks

¹Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. a.dam@obgyn.umcn.nl

Fertility and Sterility

|November 18, 2011

Summary

Intracytoplasmic sperm injection (ICSI) is effective for male infertility due to partial globozoospermia. Live birth rates in these couples match those of the general ICSI population, demonstrating successful outcomes.

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Last Updated: May 27, 2026

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Area of Science:

Reproductive Medicine
Andrology
Infertility Treatment

Background:

Partial globozoospermia, a rare sperm morphology defect, can cause male infertility.
Intracytoplasmic sperm injection (ICSI) is a key assisted reproductive technology for severe male factor infertility.

Purpose of the Study:

To evaluate the efficacy of ICSI in couples with male partial globozoospermia.
To compare ICSI outcomes in this specific group with a general ICSI population.

Main Methods:

A case-control study was conducted.
27 couples with male partial globozoospermia were matched with 263 control couples undergoing ICSI.
Live birth rate after one ICSI treatment was the primary outcome measure.

Main Results:

The live birth rate was higher in the partial globozoospermia group (66.7%) compared to the control group (50.0%).
Pregnancy outcomes, including miscarriage, birth defects, and neonatal death, were comparable between the groups.
Fertilization and live birth rates did not significantly differ from the general ICSI population.

Conclusions:

ICSI is an effective treatment for couples with male infertility due to partial globozoospermia.
The success rates of ICSI for partial globozoospermia are comparable to those in the general ICSI population.
Spontaneous conception failure within one year combined with male infertility due to partial globozoospermia indicates ICSI suitability.