Related Experiment Video
Updated: May 27, 2026

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
Published on: August 4, 2023
Internal gating and somatization disorders: proposing a yet un-described neural system
Nash N Boutros1, Rosalind Peters
1Department of Psychiatry and Behavioral Neurosciences, Wayne State University, School of Medicine, College of Nursing, Detroit, MI 48207, United States. nboutros@med.wayne.edu
Medically unexplained symptoms may arise from a failed internal sensory gating system. This system normally filters out sensations from internal organs, preventing them from reaching consciousness.
Area of Science:
- Neuroscience
- Psychosomatic Medicine
- Gastroenterology
Background:
- Medically unexplained symptoms (MUS) represent a significant healthcare burden with unclear pathophysiology.
- Chronic stress is linked to MUS, but mechanisms and symptom variability remain elusive.
Purpose of the Study:
- To propose a novel hypothesis for the development of MUS.
- To introduce the concept of an internal (visceral) sensory gating system.
Main Methods:
- The study is theoretical, proposing a hypothesis based on existing observations.
- It draws parallels with the well-established external sensory gating system.
Main Results:
- The hypothesis posits the existence of a subconscious gating mechanism for visceral sensations.
- Failure of this internal gating system could lead to the perception of symptoms indicating organ pathology.
Conclusions:
- If validated, the internal sensory gating hypothesis has significant implications for understanding and treating MUS.
- Potential applications include developing methods to assess and correct this gating system.
Related Concept Videos
Neural Regulation
Gut-Brain Axis
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Functional Brain Systems: Limbic System

