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Updated: May 27, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Proximal symphalangism and premature ovarian failure
Nadira Kadi1, Latifa Tahiri, Mariame Maziane
1Department of Rheumatology, University Hospital Center Hassan II, Fes, Morocco. nadiramede@hotmail.com
Abstract:
Proximal symphalangism is a rare autosomal dominant affection responsible for multiple joint ankylosis, it results from NOG gene mutation whose locus is on 17q21-22. This gene may be involved in secretory functions of glands such as ovarian function. Premature ovarian failure is idiopathic in 80% of cases but may be secondary to multiple etiologies including genetic. We report the case of a patient with proximal symphalangism and premature ovarian failure, and we discuss the possibility of genetic relationship between the two anomalies.
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