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Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
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Diffuse central neurocytoma with craniospinal dissemination.

Christopher J Stapleton1, Brian P Walcott, Kristopher T Kahle

  • 1Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|November 18, 2011
PubMed
Summary

Central neurocytomas (CN) are rare brain tumors. This case highlights a diffuse CN with craniospinal dissemination in a child, treated successfully with chemotherapy.

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Area of Science:

  • Neuro-oncology
  • Pediatric neurosurgery
  • Central nervous system tumors

Background:

  • Central neurocytomas (CN) are rare, benign neuroglial tumors typically found in the lateral ventricles.
  • They represent a small fraction of adult and pediatric central nervous system (CNS) tumors.
  • Localized CNs are often curable with surgical resection, with recurrence rates below 5%.

Observation:

  • This report details a rare case of a three-year-old boy diagnosed with a diffuse central neurocytoma.
  • The tumor exhibited craniospinal dissemination at the time of initial diagnosis.
  • Surgical intervention was deemed unsuitable due to the extensive nature of the tumor spread.

Findings:

  • The patient received a chemotherapy regimen comprising vincristine and carboplatin.
  • After 18 months of follow-up, the patient has completed 6 of 8 planned chemotherapy cycles.
  • Serial imaging indicates stable disease throughout the craniospinal axis.

Implications:

  • This case demonstrates the potential efficacy of chemotherapy in managing diffuse or disseminated central neurocytomas, particularly in pediatric patients.
  • It expands the understanding of treatment strategies for rare CNS tumors beyond surgical resection.
  • Further research may explore optimal chemotherapeutic protocols for similar extensive central neurocytoma cases.