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Related Concept Videos

Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...

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Updated: May 27, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

All I want for coagulation.

K P Nunn1, M R Bridgett, M R Walters

  • 1Faculty of Medicine, University of Glasgow, Glasgow, Scotland, UK.

Scottish Medical Journal
|November 18, 2011
PubMed
Summary
This summary is machine-generated.

For long flights, compression stockings with or without aspirin or heparin are evidence-based for preventing deep vein thrombosis (DVT). Simple exercises also help reduce DVT risk in travelers.

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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Last Updated: May 27, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Area of Science:

  • Medical Practice
  • Evidence-Based Medicine
  • Travel Medicine

Background:

  • Modern medicine relies on evidence-based practice.
  • Applying evidence to unique patient scenarios, like Santa Claus's DVT risk, presents challenges.
  • Deep Vein Thrombosis (DVT) is a significant concern for air travelers.

Purpose of the Study:

  • To review evidence for DVT prophylaxis in travelers.
  • To illustrate the difficulties in applying evidence to atypical clinical encounters.
  • To provide evidence-based recommendations for DVT prevention during air travel.

Main Methods:

  • Searched Medline and Cochrane Library for DVT prophylaxis studies.
  • Reviewed existing clinical guidelines for venous thromboembolism.
  • Included relevant studies and those found in reference lists.

Main Results:

  • Compression stockings are a primary evidence-based intervention.
  • A single dose of aspirin or heparin can be used adjunctively with stockings.
  • Encouraging simple in-flight exercises is also recommended.

Conclusions:

  • Compression stockings, potentially combined with aspirin or heparin, offer the most evidence-based DVT prophylaxis for high-risk travelers.
  • Simple exercises should be encouraged for all travelers on long flights.
  • The case highlights the need for adaptable evidence-based strategies in clinical practice.