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Neoinnervation in rotator cuff tendinopathy.
Yinghua Xu1, Fiona Bonar, George A C Murrell
1Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Sydney, NSW, Australia.
Early tendinopathy involves increased nerve fibers and blood vessels in human tendons, potentially causing pain. This study found higher expression of nerve markers in tendinopathic tendons compared to normal or torn ones.
Area of Science:
- Orthopedics
- Neuroscience
- Histology
Background:
- Tendinopathy is a common condition causing pain and dysfunction.
- The exact mechanisms underlying tendinopathy pain are not fully understood.
Purpose of the Study:
- To investigate the presence and location of nerves in tendinopathic human tendons.
- To compare nerve distribution in normal, tendinopathic, and torn tendons.
Main Methods:
- Human rotator cuff tendon biopsies were analyzed.
- Immunohistochemistry was used with markers for general nerves (PGP9.5), nerve regeneration (GAP43), and endothelial cells (CD34).
Main Results:
- Nerve fibers (PGP9.5, GAP43 positive) were found associated with blood vessels in tendinopathic tendons.
- Expression of PGP9.5 and GAP43 was significantly higher in tendinopathic tendons versus control and torn tendons.
Conclusions:
- Early tendinopathy is linked to increased new nerve and blood vessel growth within the tendon.
- These neovascular and neurogenic changes may contribute to the pain experienced in tendinopathy.
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