Related Experiment Videos
Imaging inflammation with 99Tcm HMPAO labelled leucocytes
J H Reynolds1, D Graham, F W Smith
1Department of Diagnostic Radiology, Aberdeen Royal Infirmary, Foresterhill, Scotland.
Clinical Radiology
|September 1, 1990
Summary
Technetium-99m hexamethylpropyleneamine oxime (HMPAO) labelled leucocyte scans accurately image inflammation. This reliable technique offers high sensitivity and specificity for detecting inflammatory conditions.
Area of Science:
- Nuclear Medicine
- Radiopharmacology
Background:
- Technetium-99m hexamethylpropyleneamine oxime (HMPAO) offers advantages over indium for leucocyte labelling in inflammation imaging.
- Assessing the reliability of 99Tcm HMPAO labelled leucocytes is crucial for clinical application.
Purpose of the Study:
- To evaluate the diagnostic accuracy and reliability of 99Tcm HMPAO labelled leucocyte scintigraphy for imaging inflammation.
- To compare the handling characteristics of 99Tcm HMPAO labelled leucocytes with indium-labelled cells.
Main Methods:
- Retrospective analysis of 43 consecutive patients undergoing 99Tcm HMPAO labelled leucocyte scintigraphy.
- Detailed assessment of cell handling properties during labelling and imaging procedures.
Main Results:
- The technique demonstrated an overall accuracy of 93.2%.
- Sensitivity was 92.8%, specificity was 93.3%, and positive predictive value was 86%.
- Hepato-biliary excretion of activity can influence interpretation.
Conclusions:
- 99Tcm HMPAO labelled leucocyte scanning is a reliable method for imaging inflammation.
- Potential interpretation errors exist due to hepato-biliary excretion, necessitating careful analysis.