Related Experiment Video
Updated: May 27, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
Comparative efficacy and effectiveness: an opportunity for clinical pharmacology
1Clinical Pharmacology, Pfizer Primary Care Business Unit, Pfizer Inc., Groton, Connecticut, USA. richard.lalonde@pfizer.com
Abstract:
Over the past 10 or more years, the drug development paradigm has shifted radically as a consequence of the availability of generic formulations for many important drugs and the growing influence of major payers in controlling reimbursement of new medicines. The demand for health care in an aging and increasingly information-seeking population is steadily outstripping society's ability to pay for all possible treatments. Regulatory approval of new drugs is necessary but no longer sufficient for market access in many countries, including the United States.
Related Concept Videos
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Bioequivalence: Overview
Dose-Response Relationship: Potency and Efficacy
Measurement of Bioavailability: Pharmacodynamic Methods
Bioequivalence of Drugs: Drugs with Multiple Indications
Pharmacodynamics: Overview and Principles
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or within...

