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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

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Updated: May 27, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Decorin in atherosclerosis.

Sandeep Singla1, Changping Hu, Adam Mizeracki

  • 1Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. ssingla@uams.edu

Therapeutic Advances in Cardiovascular Disease
|November 18, 2011
PubMed
Summary
This summary is machine-generated.

Decorin, a proteoglycan, plays a key role in preventing atherosclerosis progression. Its presence in blood vessels inversely correlates with disease development, highlighting its therapeutic potential.

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Published on: August 25, 2020

Area of Science:

  • Cardiovascular Research
  • Biochemistry
  • Extracellular Matrix Biology

Background:

  • Atherosclerotic cardiovascular disease remains a leading cause of death globally.
  • Understanding atherosclerosis pathogenesis is crucial for developing effective treatments.
  • Recent research emphasizes the extracellular matrix's role in atherosclerosis, shifting focus from purely cellular models.

Purpose of the Study:

  • To review the current understanding of decorin's role in atherosclerosis pathogenesis.
  • To highlight decorin's potential as a therapeutic target for cardiovascular disease.

Main Methods:

  • Review of in vitro and in vivo studies.
  • Analysis of human data on decorin distribution and atherosclerosis.
  • Examination of decorin's interactions with plaque components.

Main Results:

  • Decorin, a small leucine-rich proteoglycan, is implicated in attenuating atherosclerosis progression.
  • Decorin distribution inversely correlates with atherosclerosis development in different blood vessels.
  • Decorin interacts with cellular components within atherosclerotic plaques, influencing disease at multiple stages.

Conclusions:

  • Decorin is a significant factor in regulating atherosclerosis.
  • Decorin's multifaceted interactions suggest its potential as a therapeutic agent for cardiovascular diseases.