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Updated: May 27, 2026

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
Published on: April 4, 2019
Genetic informational RNA is not required for recombinant prion infectivity
Fei Wang1, Zhihong Zhang, Xinhe Wang
1Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, USA.
None:
Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.
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