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Related Concept Videos

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Oxomemazine hydro-chloride.

M S Siddegowda, Ray J Butcher, Mehmet Akkurt

    Acta Crystallographica. Section E, Structure Reports Online
    |November 18, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This study details the crystal structure of a phenothiazine derivative, 3-(5,5-dioxo-phen-othia-zin-10-yl)-N,N,2-trimethyl-propanaminium chloride. The research highlights the molecule's specific dihedral angle and intermolecular interactions within its crystal lattice.

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    Area of Science:

    • Crystallography
    • Materials Science
    • Organic Chemistry

    Background:

    • Phenothiazine derivatives are known for diverse biological and material properties.
    • Understanding the solid-state structure is crucial for predicting and optimizing compound behavior.
    • The specific compound 3-(5,5-dioxo-phen-othia-zin-10-yl)-N,N,2-trimethyl-propanaminium chloride has potential applications yet to be fully explored.

    Purpose of the Study:

    • To elucidate the crystal structure of 3-(5,5-dioxo-phen-othia-zin-10-yl)-N,N,2-trimethyl-propanaminium chloride.
    • To determine the precise molecular geometry, including key dihedral angles.
    • To identify and characterize intermolecular interactions in the crystalline state.

    Main Methods:

    • Single-crystal X-ray diffraction analysis was employed.
    • The crystal structure was solved and refined.
    • Intermolecular interactions such as hydrogen bonding and C-H···π interactions were analyzed.

    Main Results:

    • The dihedral angle between the two outer aromatic rings of the phenothiazine unit was determined to be 30.5(2)°.
    • The crystal packing is stabilized by N-H···Cl and C-H···Cl hydrogen bonds.
    • C-H···π interactions were also observed, contributing to the overall crystal structure.

    Conclusions:

    • The study provides a detailed crystallographic description of the title compound.
    • The identified intermolecular interactions offer insights into the compound's solid-state properties.
    • This structural information serves as a foundation for further research into the functional properties of this phenothiazine derivative.