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Updated: May 27, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
5,7-Dibromo-3-trifluoro-methyl-3,4-dihydro-acridin-1(2H)-one
Cosmas O Okoro1, Tasneem Siddiquee, Olugbeminiyi O Fadeyi
1Department of Chemistry, Boswell Science Complex, Tennessee State University, Nashville, 3500 John A Merritt Blvd, Nashville, TN 37209, USA.
Abstract:
In the title compound, C(14)H(8)Br(2)F(3)NO, the mol-ecule is disordered across an approximate non-crystallographic mirror plane, which is in the plane of the fused ring system [The tetrahedral C atom bearing the trifluormethyl substituent is disordered with site occupancy factors of 0.80 (2) and 0.20 (2)]. In the crystal, a one-dimensional stacking of mol-ecules involves inter-actions between the pyridine ring and symmetry-related Br and O atoms of adjacent mol-ecules. The stacking distance between the mean planes of adjacent mol-ecules is 3.395 (4) Å.
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