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Updated: May 27, 2026
08:03
In Vitro Model of Coronary Angiogenesis
Published on: March 10, 2020
Coronary angiogenesis during experimental hypertension: is it reversible?
Mohammad Zarei1, Majid Khazaei, Mohammad Reza Sharifi
1Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Summary
Reversing renovascular hypertension in rats normalized blood pressure and restored serum vascular endothelial growth factor (VEGF) and soluble receptor-1 (sFlt-1) levels. These findings highlight the importance of early hypertension diagnosis and treatment.
Area of Science:
- Cardiovascular Research
- Renal Physiology
- Angiogenesis Studies
Background:
- Investigated coronary angiogenesis and serum vascular endothelial growth factor (VEGF) and its soluble receptor-1 (sFlt-1) in two-kidney one-clip (2K1C) hypertensive rats.
- Examined changes before and after the reversal of hypertension.
Purpose of the Study:
- To determine the impact of hypertension reversal on coronary angiogenesis.
- To assess changes in serum VEGF and sFlt-1 concentrations following hypertension treatment.
Main Methods:
- Utilized four groups of rats: sham-clipped, 2K1C hypertensive, sham-clipped then unclipped, and 2K1C hypertensive then unclipped.
- Measured blood pressure, serum VEGF and sFlt-1 levels, and capillary density before and after interventions.
Main Results:
- Hypertensive rats exhibited elevated blood pressure compared to controls.
- Unclipping significantly reduced blood pressure and normalized serum VEGF and sFlt-1 levels.
- Coronary capillary density in hypertensive rats was initially higher but returned to normal levels after unclipping.
Conclusions:
- Changes in capillary density and serum VEGF/sFlt-1 in renovascular hypertension are reversible.
- Early diagnosis and treatment of hypertension are crucial for clinical outcomes.
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