Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventilatory and diffusion abnormalities in potential heart transplant recipients.

R S Wright1, M S Levine, P E Bellamy

  • 1Department of Medicine, UCLA School of Medicine 90024-1690.

Chest
|October 1, 1990
PubMed
Summary

Severe chronic heart failure frequently causes impaired lung diffusion, often with restrictive or obstructive defects. This finding is crucial for heart transplant candidates, impacting post-transplant lung function assessments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Panlobular emphysema is associated with COPD disease severity: A study of emphysema subtype by computed tomography.

Respiratory medicine·2022
Same author

The safety of anticholinergic bronchodilators for the treatment of chronic obstructive pulmonary disease.

Expert opinion on drug safety·2015
Same author

Authors' response to Walker et al.

Thorax·2013
Same author

Quality and reproducibility of spirometry in COPD patients in a randomized trial (UPLIFT®).

Respiratory medicine·2013
Same author

Lung function and respiratory symptoms in a 1-year randomized smoking cessation trial of varenicline in COPD patients.

Respiratory medicine·2011
Same author

Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis.

Allergy·2011

Area of Science:

  • Pulmonary Medicine
  • Cardiology
  • Critical Care Medicine

Background:

  • Limited data exist on pulmonary function in severe chronic congestive heart failure.
  • Patients evaluated for cardiac transplantation often present with advanced heart disease.

Purpose of the Study:

  • To investigate pulmonary function abnormalities in patients with severe chronic congestive heart failure.
  • To identify the prevalence and patterns of lung function defects in this population.

Main Methods:

  • Pulmonary function tests were performed on 132 patients with severe heart failure (mean ejection fraction 19%, cardiac index 2.1 L/min/m2).
  • Data were analyzed to identify diffusion, restrictive, and obstructive ventilatory defects.

Main Results:

Related Experiment Videos

  • 67% of patients exhibited diffusion impairment, alone or with other defects.
  • Diffusion impairment as the sole abnormality was seen in 31%; combined with restrictive defects in 21%.
  • Obstructive defects were uncommon, unlike in acute heart failure studies.

Conclusions:

  • Diffusion impairment is a frequent, previously undescribed finding in severe chronic congestive heart failure.
  • Lung function abnormalities were not associated with clinical or hemodynamic factors.
  • Understanding these pulmonary changes is vital for interpreting post-heart transplant lung function.