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Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Common data elements for research on traumatic brain injury: pediatric considerations.

A Cate Miller¹, Joanne Odenkirchen, Ann-Christine Duhaime

¹National Institute on Disability and Rehabilitation Research , United States Department of Education, Washington, DC 20202, USA. cate.miller@ed.gov

Journal of Neurotrauma

|November 19, 2011

Summary

Standardizing common data elements (CDEs) is crucial for pediatric traumatic brain injury (TBI) research. This initiative refined CDEs to improve data sharing and advance TBI treatment evidence for children and adolescents.

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Last Updated: May 27, 2026

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Published on: August 16, 2019

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Published on: January 20, 2023

Area of Science:

Neuroscience
Public Health
Pediatrics

Background:

Traumatic brain injury (TBI) presents a major global health challenge, particularly affecting children and adolescents.
Research limitations in TBI treatment stem from study heterogeneity and inconsistent data measurement, hindering effective interventions.
Standardizing definitions and data elements is vital for advancing TBI research and improving patient outcomes.

Purpose of the Study:

To review and update common data elements (CDEs) for traumatic brain injury (TBI) research, focusing on pediatric populations.
To ensure CDEs are relevant and applicable to the unique aspects of pediatric TBI.
To facilitate data sharing and enhance the evidence base for pediatric TBI treatment.

Main Methods:

Formation of multidisciplinary expert work groups (Demographics/Clinical Assessment, Biomarkers, Neuroimaging, Outcomes Assessment) for pediatric TBI.
Review and modification of existing TBI CDEs based on pediatric considerations.
Vetting and refinement of recommendations through workshops and expert consensus.

Main Results:

Developed updated CDE recommendations tailored for pediatric TBI research.
Identified specific modifications and additions to existing CDEs for pediatric populations.
Established a structured process for CDE development and refinement.

Conclusions:

The pediatric TBI CDE initiative provides a foundation for more consistent and comparable research.
Standardized CDEs will accelerate data sharing, leading to a stronger evidence base for pediatric TBI interventions.
Recommendations guide future iterations of the CDE initiative for ongoing improvement in TBI research.