Related Experiment Video
Updated: May 27, 2026
11:44
Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants
Published on: May 13, 2015
Rhodococcus equi: clinical manifestations, virulence, and immunity.
S Giguère1, N D Cohen, M Keith Chaffin
1Department of Large Animal Medicine, University of Georgia, Athens, GA 30602, USA. gigueres@uga.edu
Journal of Veterinary Internal Medicine
|November 19, 2011
Summary
Rhodococcus equi causes significant foal pneumonia and death. This review details its clinical signs, virulence, and immunity, aiding in foal health management.
Area of Science:
- Veterinary Medicine
- Equine Health
- Microbiology
Background:
- Pneumonia is a leading cause of mortality in foals.
- Rhodococcus equi, a gram-positive facultative intracellular pathogen, is a primary bacterial agent responsible for foal pneumonia.
- Understanding R. equi infections is crucial for equine veterinary practice.
Purpose of the Study:
- To review the clinical manifestations of Rhodococcus equi infections in foals.
- To summarize current knowledge on the virulence mechanisms of R. equi.
- To consolidate information on immunity against R. equi in foals.
Main Methods:
- Literature review of clinical cases and research studies on Rhodococcus equi.
- Synthesis of information on bacterial pathogenesis and host immune responses.
- Cross-referencing with a complementary consensus statement on diagnosis, treatment, and prevention.
Main Results:
- Rhodococcus equi infections present with specific clinical signs in foals.
- Virulence factors of R. equi contribute to disease development.
- Immune responses in foals play a critical role in controlling R. equi.
Conclusions:
- Effective management of foal pneumonia requires a thorough understanding of Rhodococcus equi.
- Further research into virulence and immunity can inform improved treatment and prevention strategies.
- This review serves as a foundational resource for equine practitioners dealing with R. equi infections.
More Related Videos
10:29Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing
Published on: July 6, 2016
06:13Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses
Published on: November 24, 2014
Related Concept Videos
01:28Diphtheria
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:28Regulation of Bacterial Virulence
Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
01:28Infectious Diseases and Their Occurrence
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...