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Related Experiment Video

Updated: May 27, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Photosensitivity induced by naproxen.

Enrique Gutiérrez-González¹, Laura Rodríguez-Pazos, Maria Teresa Rodríguez-Granados

¹Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, Spain. egutgon@hotmail.com

Photodermatology, Photoimmunology & Photomedicine

|November 19, 2011

Summary

Systemic photosensitivity can occur from naproxen, a common nonsteroidal anti-inflammatory drug (NSAID). Two cases presented with photodistributed erythema multiforme and lichenoid photodermatitis, confirmed by photopatch testing and UVB normalization.

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Last Updated: May 27, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Area of Science:

Dermatology
Pharmacology

Background:

Systemic photosensitivity is a known adverse reaction to certain medications.
Naproxen, a widely used nonsteroidal anti-inflammatory drug (NSAID), has the potential to induce photosensitivity.
Reports detailing naproxen-induced photosensitivity are infrequent in medical literature.

Observation:

Two patients presented with distinct skin reactions following naproxen ingestion.
The observed reactions included photodistributed erythema multiforme (EM) and lichenoid photodermatitis (LP).
The clinical presentation suggested a drug-induced photosensitivity reaction.

Findings:

Diagnosis was supported by the temporal relationship between naproxen ingestion and the onset of skin lesions.
Photodistributed lesions were a key diagnostic clue.
Diagnostic confirmation included a positive photopatch test in one patient and normalization of minimal erythema dose (MED) with UVB in the other after naproxen cessation.

Implications:

This highlights the importance of considering naproxen as a potential cause of systemic photosensitivity.
Clinicians should be aware of these potential adverse reactions when prescribing NSAIDs.
Further investigation into naproxen-induced photosensitivity may be warranted.