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Updated: May 27, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Comparative investigation of the effects of different materials used with a titanium barrier on new bone formation
Şeref Ezirganlı1, Serkan Polat, Emre Barış
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, 34093- İstanbul, Turkey. seref.ezirganli@gmail.com
Objectives:
In this study, we aimed to study the effects on new bone formation of autogenous blood, deproteinized bovine bone graft (DBBG), and biphasic calcium phosphate (BCP) bioceramic graft materials placed under titanium barriers.
Material And Methods:
Twenty-four adult male New Zealand white rabbits were used in this study. Two titanium barriers were fixed on each rabbit's calvarium. The study included four groups, one of which was a control group. The experiment groups, autogenous blood, DBBG (Bio-Oss(®) ; Geistlich Biomaterials, Wolhusen, Switzerland) and BCP (4Bone(TM) ; Biomatlante, Vigneux de Bretagne, France) were placed under titanium barriers; in the control group, no materials were used. Half of the animals were sacrificed after 1 month, and the rest were sacrificed after 3 months. After this, micro-computerized tomography images were taken, and a histomorphometric evaluation was carried out.
Results:
The amounts of new bone formation were found to be higher at the third month than at the first month. The differences between the groups were examined with both a micro-computerized tomography and histomorphometric analysis, and no statistical significance was noted in the first month. In contrast, the increase in the amount of new bone formation at the third month was found to be statistically significant only between the DBBG and control groups (P < 0.05).
Conclusion:
Autogenous blood with titanium barriers in guided bone regeneration seems to be as successful as DBBG and BCP bioceramic graft material.
