Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 27, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Published on: February 2, 2024

Soft tissue surrounding switched platform implants: an immunohistochemical evaluation.

Claudia Dellavia¹, Luigi Canullo, Cristina Allievi

¹Department of Human Morphology and Biomedical Sciences Città Studi, Università degli Studi di Milano, Milan, Italy.

Clinical Oral Implants Research

|November 19, 2011

Summary

Implant abutment configuration does not affect the inflammatory response or cellular patterns linked to bone loss around dental implants. This suggests the interface design may not be a primary driver of peri-implant inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diachronic Trends in Dental Hygiene Over the Last 2000 Years in Milan, Italy: An Exploratory Study.

International journal of dental hygiene·2026

Same author

Digitally Guided Transcrestal Sinus Floor Elevation Using Collagenated Synthetic Hydroxyapatite or Collagenated Xenograft: Histologic and Volumetric Comparison.

Journal of dentistry·2026

Same author

Large Language Models and Retrieval-Augmented Platforms for Dental Implant Complications: A Blinded, Expert-Rated Benchmarking Study.

Journal of dentistry·2026

Same author

Histological evaluation of the soft tissue response to plasma-activated healing abutments: A prospective controlled clinical trial.

Journal of prosthodontic research·2026

Same author

Clinical outcomes of post-extractive tissue-level implants with transmucosal zirconia collar: a prospective cohort study.

Oral and maxillofacial surgery·2026

Same author

Prevention of initial bone remodelling around dental implants: An international clinical consensus utilising the Delphi method.

International journal of oral implantology (Berlin, Germany)·2026

Area of Science:

Dental Implantology
Immunohistochemistry
Periodontology

Background:

Peri-implant bone loss is a significant concern in restorative dentistry.
Understanding the inflammatory mechanisms driving bone loss is crucial for improving implant longevity.

Purpose of the Study:

To investigate how different implant platform configurations influence the cellular and molecular factors associated with soft tissue bone loss around dental implants.
To characterize the immunohistochemical patterns of inflammatory markers in response to varying abutment mismatches.

Main Methods:

A 4-year clinical study involving 32 implants with varying abutment mismatches (0 mm, 0.25 mm, 0.5 mm, 0.85 mm).
Soft tissue samples were analyzed for T lymphocytes (LyT), B lymphocytes (LyB), IL-17, and RANKL expression using immunohistochemistry.

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Related Experiment Videos

Last Updated: May 27, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Published on: February 2, 2024

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Statistical analysis was performed to compare groups and assess correlations between markers.

Main Results:

No significant differences in T and B cell counts, IL-17, or RANKL expression were observed between the different abutment mismatch groups.
Pooled data indicated higher counts of lymphocytes T and IL-17 compared to lymphocytes B and RANKL.
Strong negative correlations were found between LyT and LyB counts, and moderate correlations between IL-17 and lymphocyte counts.

Conclusions:

The configuration of the implant abutment interface does not appear to influence the inflammatory cellular and molecular patterns contributing to bone loss.
These findings suggest that factors other than abutment design may be more critical in driving peri-implant inflammatory processes and subsequent bone loss.