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Related Concept Videos

Surface Active Agents01:27

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...

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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
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Published on: July 27, 2022

Eudragit E100 surface activity and lipid interactions.

Roxana V Alasino1, Victoria Leonhard, Ismael D Bianco

  • 1Centro de Excelencia en Productos y Procesos de Córdoba (CEPROCOR), Ministerio de Ciencia y Tecnología de Córdoba, Santa María de Punilla, Córdoba, Argentina.

Colloids and Surfaces. B, Biointerfaces
|November 19, 2011
PubMed
Summary
This summary is machine-generated.

Eudragit E100 (E100), a cationic polymer, effectively penetrates model membranes by altering its surface activity based on pH, ionic strength, and lipid composition. Its interaction with different lipid monolayers highlights its adaptable amphipathic nature.

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Area of Science:

  • Polymer science
  • Surface chemistry
  • Biomembrane interactions

Background:

  • Eudragit E100 (E100) is a cationic methacrylate polymer with known interactions with viral and cell membranes.
  • Understanding its behavior at interfaces is crucial for applications involving membrane penetration.

Purpose of the Study:

  • To investigate the surface activity of Eudragit E100.
  • To determine the influence of pH, ionic strength, and lipid monolayers on E100's interfacial behavior.

Main Methods:

  • Studied E100 adsorption at the air-water interface.
  • Varied subphase pH and ionic strength.
  • Investigated interactions with cholesterol, monosialoganglioside, and hydrogenated soy lecithin lipid monolayers.
  • Examined E100 interaction with GM1 micelles.

Main Results:

  • E100 forms stable monolayers at the air-water interface, influenced by pH and ionic strength.
  • Adsorption is rapid at pH ≥ 5 and low ionic strength (10 mM).
  • E100 shows strong adsorption to anionic and non-ionic lipid monolayers but weak interaction with zwitterionic lipids.

Conclusions:

  • Eudragit E100 effectively penetrates model membranes.
  • Its amphipathic character is significantly modulated by the aqueous environment and lipid composition.
  • E100's surface activity is tunable for potential membrane-related applications.