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Related Experiment Video

Updated: May 27, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Metformin intoxication requiring dialysis.

Hoang-Lan Nguyen¹, Luis Concepcion

¹Scott & White Hospital, Texas A&M Health Science Center, Temple, Texas, USA. Lnguyen726@hotmail.com

Hemodialysis International. International Symposium on Home Hemodialysis

|November 19, 2011

Summary

This summary is machine-generated.

Metformin (MTF) intoxication can cause severe lactic acidosis and high mortality. Hemodialysis effectively removes MTF and corrects metabolic abnormalities in patients with metformin toxicity.

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Area of Science:

Nephrology
Toxicology
Internal Medicine

Background:

Metformin is a common oral antidiabetic agent.
Metformin intoxication is a serious condition associated with lactic acidosis and significant mortality.
Dialytic intervention is sometimes required for severe cases.

Observation:

This study analyzed 12 patients with metformin intoxication requiring dialysis between 2005 and 2010.
Ten patients were treated with conventional hemodialysis (HD) or continuous veno-venous hemodialysis (CVVHD) using bicarbonate dialysis.
Patients presented with acute kidney injury, severe lactic acidosis, and elevated metformin levels.

Findings:

Hemodialysis, both conventional and continuous, effectively reduced metformin levels by approximately 60% and improved metabolic parameters, including lactic acidosis and bicarbonate levels.
No significant difference in efficacy was observed between conventional HD and CVVHD.
Mortality was 25%, with older age being a significant factor differentiating survivors from non-survivors.

Implications:

Metformin toxicity is a critical clinical condition requiring prompt management.
Hemodialysis is an efficient and effective treatment for metformin intoxication, correcting severe lactic acidosis and reducing drug levels.
Age is a key prognostic factor in metformin toxicity outcomes.