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Related Experiment Video

Updated: May 27, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Circulating angiogenic cell populations, vascular function, and arterial stiffness.

Susan Cheng¹, Na Wang, Martin G Larson

¹Framingham Heart Study, Framingham, MA 02118, United States.

Atherosclerosis

|November 19, 2011

Summary

Lower levels of circulating angiogenic cells, such as CD34+ cells, were not significantly linked to impaired vascular function or arterial stiffness in a large study. These findings suggest these cell types may not be reliable indicators for cardiovascular health in the general population.

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Published on: June 3, 2019

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Last Updated: May 27, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

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Published on: October 19, 2016

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Area of Science:

Cardiovascular Research
Cell Biology
Vascular Medicine

Background:

Bone marrow-derived cells are investigated for their role in vascular homeostasis and angiogenesis.
Circulating angiogenic cells (CACs) are potential biomarkers for vascular health.
Impaired vascular function and arterial stiffness are key indicators of cardiovascular risk.

Purpose of the Study:

To investigate the association between circulating angiogenic cell phenotypes and vascular function.
To determine if lower quantities of CACs correlate with increased arterial stiffness.
To examine the relationship between CD34+, CD34+/KDR+ cells, and early outgrowth colony-forming units (CFU) with vascular parameters.

Main Methods:

A cohort of 1948 participants from the Framingham Heart Study was analyzed.
Phenotyping of circulating angiogenic cells included CD34+, CD34+/KDR+, and CFU.
Vascular function was assessed using peripheral arterial tone (PAT), arterial tonometry, and brachial reactivity testing.

Main Results:

Unadjusted analyses showed associations between higher CD34+ and CD34+/KDR+ levels and altered peripheral arterial tone and pulse wave velocity.
These associations were largely attenuated in multivariable analyses, with only lower CD34+ and higher PAT ratio remaining significant.
Colony-forming units (CFU) showed no association with vascular function or arterial stiffness measures.

Conclusions:

Circulating angiogenic cell phenotypes, including CD34+ and CD34+/KDR+, were generally not associated with vascular function or arterial stiffness in a large, community-based sample after adjusting for traditional cardiovascular risk factors.
The findings suggest that these specific CAC phenotypes may not serve as independent biomarkers for vascular health in the general population.
Further research may be needed to explore other angiogenic cell populations or different methodologies for assessing their clinical relevance.