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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
T Cell Types and Functions01:24

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Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Secondary Spinal Cord Injury llI: Pathophysiology01:25

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Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

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[Central nervous system involvement in systemic sclerosis].

F Ajili1, A Mersni, L Métoui

  • 1Service de médecine interne, hôpital militaire de Tunis, Montfleury 1008 Tunis, Tunisie. faida1977@yahoo.fr

La Revue De Medecine Interne
|November 19, 2011
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis can affect the central nervous system, contrary to previous beliefs. Brain imaging revealed cerebral vasculitis in a patient, which improved with treatment.

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Area of Science:

  • Neurology
  • Immunology
  • Radiology

Background:

  • Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and internal organs.
  • Central nervous system (CNS) involvement in SSc is considered rare, though debated by recent advancements in neuroimaging.

Observation:

  • A 56-year-old woman with a history of SSc since 2005 developed cerebellar and pyramidal signs four years later.
  • Cerebral magnetic resonance imaging (MRI) revealed signs consistent with cerebral vasculitis.

Findings:

  • The patient received a treatment regimen including corticosteroids, cyclophosphamide pulses, and azathioprine for maintenance.
  • Clinical and radiological outcomes were favorable, indicating successful management of the CNS involvement.

Implications:

  • Cerebral MRI findings in SSc patients with neurological symptoms may indicate CNS involvement, especially when other causes are ruled out.
  • This case highlights the importance of considering CNS vasculitis in the differential diagnosis of neurological complications in systemic sclerosis.