Related Experiment Video
Updated: May 27, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
[Effects of mechanical ventilation and positive end-expiratory on central venous pressure]
Li-ming Yang1, Jing Tan, Wan-li Yang
1Department of Critical Care Medicine, Affiliated Taiyuan Steel General Hospital, Shanxi Medical University, Taiyuan 030003, China. tgylm1970@163.com
Objective:
To investigate the effects of mechanical ventilation and positive end expiratory pressure (PEEP) on central venous pressure (CVP).
Methods:
Forty cases of respiratory failure with mechanical ventilation were enrolled. Catheter was inserted via subclavian vein in each. And then CVP was measured without mechanical ventilation and under different PEEP conditions of 0, 6 and 12 cm H2O.
Results:
Mechanical ventilation could affect the levels of CVP, P(peak) ≈ PS+PEEP, followed PEEP, t = 3.364, P = 0.006. There was significant difference was found among the three groups, F = 15.293, P = 0.000. And CVP increased with a rising level of PEEP.
Conclusion:
Mechanical ventilation and PEEP affect the accuracy of CVP.
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