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Updated: May 27, 2026

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Published on: May 10, 2024
[Relationship between methylenetetrahydrofolate reductase gene C677T polymorphism and susceptibility of ischemic
Hui-hui Yu1, Wen-liang Zhang, Jing-pu Shi
1Department of Clinical Epidemiology, China Medical University, Shenyang, China.
Objective:
To evaluate the relationship between the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and the susceptibility of ischemic stroke among different ethnic populations.
Methods:
The databases of MEDLINE, EMBASE, Cochrane Library and others were searched. And a total of 17 studies published in English between 2000 and October 2010 on the association of MTHFR gene C677T polymorphism with ischemic stroke were selected. A comprehensive quantitative analysis was performed by meta-analysis.
Results:
The results showed that the pooled OR values of ischemic stroke with TT and CC genotype were 1.30 (95%CI: 1.11 to 1.52) and 0.88 (95%CI: 0.79 to 0.98) respectively. And when sub-grouped by ethnic populations, the Caucasians were more likely than other populations to suffer ischemic stroke. There was a low probability of publication bias.
Conclusion:
The presence of MTHFR TT gene is associated with an elevated risk of developing ischemic stroke, especially in Caucasians.
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