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Related Experiment Video

Updated: May 27, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Published on: May 6, 2009

Chronological aging in Saccharomyces cerevisiae.

Valter D Longo¹, Paola Fabrizio

¹Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, Los Angeles, CA, 90089-0191, USA, vlongo@usc.edu.

Sub-Cellular Biochemistry

|November 19, 2011

Summary

Yeast aging studies, using chronological life span (CLS) and replicative life span (RLS), reveal molecular mechanisms for healthy aging. Research highlights pathways like Tor/Sch9 and Ras/PKA, focusing on oxidative stress and DNA repair.

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Published on: September 29, 2011

Area of Science:

Gerontology
Molecular Biology
Yeast Genetics

Background:

Aging research utilizes two main yeast models: chronological life span (CLS) and replicative life span (RLS).
CLS measures survival of non-dividing cells; RLS quantifies daughter cells produced by a mother cell.
Understanding yeast aging provides insights into fundamental aging processes and healthy aging in mammals.

Purpose of the Study:

To review key discoveries in yeast chronological aging.
To explore molecular mechanisms underlying aging and healthy aging.
To emphasize the roles of specific signaling pathways and cellular damage in aging.

Main Methods:

Review of principal discoveries in yeast chronological aging research.
Focus on life span regulation by Tor/Sch9 and Ras/adenylate cyclase/PKA pathways.
Emphasis on age-dependent oxidative stress and DNA damage/repair mechanisms.

Main Results:

Yeast aging models contribute to understanding aging processes relevant to mammals.
The Tor/Sch9 and Ras/PKA pathways are critical regulators of life span.
Oxidative stress and DNA damage are significant factors in age-related decline.

Conclusions:

Yeast aging research offers valuable insights into conserved aging mechanisms.
Targeting specific pathways and mitigating cellular damage may promote healthy aging.
Further investigation into yeast aging can inform strategies for human longevity.