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Related Concept Videos

Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.

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Updated: May 27, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
12:24

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Published on: May 6, 2009

Yeast aging and apoptosis.

Peter Laun1, Sabrina Büttner, Mark Rinnerthaler

  • 1Division of Genetics, Department of Cell Biology, University of Salzburg, Salzburg, Austria, peter.laun@sbg.ac.at.

Sub-Cellular Biochemistry
|November 19, 2011
PubMed
Summary
This summary is machine-generated.

Maintaining a balance between cell proliferation and apoptosis is vital for multicellular life. Yeast, possessing conserved apoptotic machinery, offer a powerful model to study the intricate links between aging and programmed cell death.

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Area of Science:

  • Cell Biology
  • Aging Research
  • Genetics

Background:

  • Apoptosis, or programmed cell death, is crucial for organismal development and survival.
  • A balance between cell proliferation and apoptosis is essential for multicellular organisms.
  • Yeast exhibit conserved apoptotic machinery, making them a valuable model for studying aging.

Purpose of the Study:

  • To investigate the relationship between aging and apoptosis using yeast as a model system.
  • To explore the role of apoptosis in yeast aging processes (replicative and chronological).

Main Methods:

  • Utilizing yeast genetics and powerful molecular tools.
  • Investigating complex physiological and cytological interactions in yeast.
  • Analyzing conserved apoptotic pathways in a model organism.

Main Results:

  • Yeast possess functional and conserved apoptotic machinery.
  • Yeast aging (replicative and chronological) is closely linked to apoptosis.
  • Experimental evidence highlights yeast as a versatile system for studying aging-apoptosis interconnections.

Conclusions:

  • Yeast provide a powerful model for understanding the complex interplay between aging and apoptosis.
  • Further research in yeast can elucidate the causal relationship between apoptosis and the aging process.