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Updated: May 27, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
[Treatment of non-small cell lung cancer]
N Reinmuth1, D Heigener, M Reck
1Internistische Onkologie der Thoraxtumoren, Thoraxklinik am Universitätsklinikum Heidelberg, Amalienstrasse 5, Heidelberg, Germany. niels.reinmuth@thoraxklinik-heidelberg.de
Abstract:
Within recent years, the treatment of non-small cell lung cancer has become increasingly heterogeneous and complex. New cytotoxic agents and drugs against molecular targets have been developed. Moreover, new indications for therapy such as maintenance therapy have been explored. In addition, by assessing defined molecular markers, it is possible to identify patients who may likely respond to a given treatment. This approach will continue in the future; thus, it will be possible to characterize patient into subgroups based on molecular, histological, or clinical markers. This review will summarize the current state of the art in the treatment of non-small cell lung cancer.
Insights
Treatment for non-small cell lung cancer is evolving with new targeted therapies and maintenance strategies. Molecular markers are crucial for personalizing treatment by identifying patient subgroups likely to respond.
Area of Science:
- Oncology
- Pharmacology
Context:
- Non-small cell lung cancer (NSCLC) treatment landscape is rapidly evolving.
- Increasing complexity due to new therapeutic agents and strategies.
Purpose:
- To review the current state of non-small cell lung cancer treatment.
- Highlight advancements in cytotoxic agents and molecularly targeted drugs.
- Discuss emerging therapeutic indications like maintenance therapy.
Summary:
- Recent advancements include novel cytotoxic agents and molecularly targeted drugs for NSCLC.
- Molecular markers are key to identifying patient subgroups for personalized therapy.
- Future treatment will increasingly rely on stratifying patients by molecular, histological, or clinical markers.
Impact:
- Personalized medicine approaches are transforming NSCLC patient care.
- Improved patient outcomes are expected through tailored treatment strategies.
- This review provides a comprehensive overview for clinicians and researchers in the field.
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