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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Tocotrienol as a potential anticancer agent.

Ming T Ling1, Sze U Luk, Fares Al-Ejeh

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Tocotrienols (T3), a form of vitamin E, show potent anticancer effects superior to tocopherols (TP). T3 demonstrates promise in cancer treatment and prevention, including chemosensitization and anti-cancer stem cell activity.

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Area of Science:

  • Nutritional biochemistry
  • Oncology
  • Molecular medicine

Background:

  • Vitamin E comprises tocopherols (TP) and tocotrienols (T3).
  • Tocotrienols (T3) are emerging as potent anticancer agents, surpassing tocopherols (TP) in efficacy.
  • T3 exhibits anticancer properties beyond traditional antioxidant and pro-apoptotic functions.

Purpose of the Study:

  • To review the anticancer effects of tocotrienols (T3).
  • To summarize recent advancements in understanding T3's mechanisms against cancer.
  • To discuss the clinical progress of T3 in cancer therapy.

Main Methods:

  • Literature review of preclinical and clinical studies on tocotrienols (T3).
  • Analysis of T3's molecular mechanisms in cancer inhibition.
  • Evaluation of T3's role in chemoprevention and adjuvant cancer therapy.

Main Results:

  • T3 inhibits epithelial-to-mesenchymal transitions and tumor angiogenesis via VEGF.
  • T3 demonstrates chemosensitization and anti-cancer stem cell effects.
  • T3 shows potential for inducing antitumor immunity.

Conclusions:

  • Tocotrienols (T3) represent a promising next-generation vitamin E for cancer chemoprevention and treatment.
  • T3's unique anticancer properties warrant further clinical investigation as an adjuvant therapy.
  • Research is shifting towards T3 due to disappointing clinical outcomes with TP.