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Related Concept Videos

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Related Experiment Video

Updated: May 27, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
04:41

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Is photodynamic therapy a solution for keloid?

Z Nie1

  • 1University of Manchester, Manchester, UK. Zhuxiang.nie@manchester.ac.uk

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|November 19, 2011
PubMed
Summary
This summary is machine-generated.

Photodynamic therapy (PDT) shows promise for treating keloids, a common skin condition. This novel approach may improve keloid treatment outcomes by targeting skin cells and collagen, potentially leading to scarless healing.

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An In Vitro Approach to Photodynamic Therapy
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An In Vitro Approach to Photodynamic Therapy

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Last Updated: May 27, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
04:41

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

An In Vitro Approach to Photodynamic Therapy
04:53

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

Area of Science:

  • Dermatology
  • Photomedicine
  • Wound Healing

Background:

  • Keloids are a prevalent and challenging skin condition, particularly in individuals of Asian and African descent.
  • Current keloid treatments remain largely unsatisfactory, necessitating the exploration of novel therapeutic strategies.
  • Photodynamic therapy (PDT), known for its efficacy and safety in treating skin pre-malignant and malignant lesions, offers potential for keloid management.

Purpose of the Study:

  • To explore the potential of 5-aminolevulinic acid (ALA) or methylaminolevulinate (MAL)-based photodynamic therapy (PDT) for treating keloids and hypertrophic scars.
  • To investigate the underlying mechanisms by which PDT may exert therapeutic effects on keloid tissues.
  • To consider the scope and application of topical PDT for keloid treatment.

Main Methods:

  • Review of independent reports on the efficacy of ALA or MAL-PDT in keloid and hypertrophic scar treatment.
  • Analysis of potential mechanisms of action, including effects on keratinocytes, fibroblasts, and extracellular matrix (ECM).
  • Consideration of PDT's ability to induce apoptosis/necrosis in keloid fibroblasts and modulate growth factors and cytokines.

Main Results:

  • Preliminary reports suggest that ALA or MAL-PDT may be effective in treating keloids and hypertrophic scars.
  • PDT's mechanism in keloid treatment is not fully understood but may involve modulating cellular and extracellular components.
  • PDT is associated with inflammation but also exhibits scarless or minimal scarring wound healing properties.

Conclusions:

  • Topical photodynamic therapy presents a promising, novel treatment avenue for keloids, addressing the limitations of current therapies.
  • Further research into the precise mechanisms of PDT in keloid pathogenesis is warranted to optimize treatment protocols.
  • PDT's unique ability to promote healing with minimal scarring makes it an attractive option for managing keloid scarring.