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Updated: May 27, 2026
06:48
Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
Published on: March 23, 2022
Lyell syndrome due to ticlopidine.
D Strippoli1, G Russo, V Simonetti
1Department of Dermatology, Lecco Hospital, Lecco, Italy.
Summary
The antiplatelet drug ticlopidine can cause toxic epidermal necrolysis (TEN), a rare but severe skin reaction. High-dose intravenous immunoglobulin therapy led to full recovery in a patient experiencing this adverse event.
Area of Science:
- Pharmacology
- Dermatology
- Internal Medicine
Background:
- Ticlopidine is an antiplatelet medication commonly prescribed for cardiomyopathies, coronary cardiopathies, and thromboembolic disorders.
- Common side effects include diarrhea, hematological dyscrasias, and rashes.
Observation:
- A rare case of toxic epidermal necrolysis (TEN) was observed in a patient undergoing treatment with ticlopidine.
- The adverse event was triggered during the treatment and prophylaxis of transient ischemic attacks.
Findings:
- The study details the clinical-pathological aspects of ticlopidine-induced toxic epidermal necrolysis.
- High-dose intravenous immunoglobulin therapy was administered as a treatment intervention.
Implications:
- This case highlights a rare but serious adverse reaction to ticlopidine, emphasizing the need for vigilant monitoring.
- Intravenous immunoglobulin therapy demonstrated efficacy in achieving full recovery from toxic epidermal necrolysis, suggesting a potential therapeutic strategy.
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