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Published on: February 23, 2014
Sleep-disordered breathing is a risk factor for community-acquired alveolar pneumonia in early childhood
Aviv D Goldbart1, Asher Tal1, Noga Givon-Lavi2
1Sleep-Wake Disorders Unit, Ben-Gurion University of the Negev, Beer Sheva, Jerusalem, Israel; Department of Pediatrics, Ben-Gurion University of the Negev, Beer Sheva, Jerusalem, Israel.
Insights
Sleep-disordered breathing (SDB) is a significant risk factor for community-acquired alveolar pneumonia (CAAP) in young children. Early identification and management of SDB can help prevent CAAP in this vulnerable population.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Infectious Diseases
Background:
- Limited data exists on risk factors for childhood community-acquired alveolar pneumonia (CAAP).
- Children with sleep-disordered breathing (SDB) are known to have increased respiratory infections.
- The study investigated SDB as a potential risk factor for CAAP in early childhood.
Purpose of the Study:
- To assess if sleep-disordered breathing (SDB) is a risk factor for community-acquired alveolar pneumonia (CAAP) in children under 5 years old.
Main Methods:
- A prospective, nested case-control study was conducted.
- Children under 5 with radiographically confirmed CAAP were compared to controls.
- SDB symptoms were assessed via questionnaire and polysomnography (PSG).
Main Results:
- Children with CAAP reported significantly more SDB symptoms like snoring and restless sleep compared to controls.
- Adenoidectomy rates were higher in the CAAP group.
- Obstructive sleep apnea (OSA) was diagnosed in 5% of CAAP patients versus 1.3% of controls (OR, 3.7).
Conclusions:
- Sleep-disordered breathing (SDB) is prevalent in children with CAAP.
- SDB may be a predisposing risk factor for CAAP in young children.
- Consideration of SDB is recommended for young children diagnosed with CAAP.
Background:
Data are scarce with regard to risk factors for acute community-acquired alveolar pneumonia (CAAP) in children, but it is known that children with sleep-disordered breathing (SDB) experience more respiratory infections. We aimed to assess whether SDB is a risk factor for CAAP in early childhood.
Methods:
We conducted a prospective, nested, case-control study assessing children < 5 years old who had been given a diagnosis of CAAP based on World Health Organization radiographic criteria. Demographic and clinical data were collected. SDB symptoms were documented using a structured questionnaire. CAAP study and retrospective sleep laboratory databases were compared. SDB presence and severity were determined by questionnaire and polysomnography (PSG).
Results:
A total of 14,913 children underwent chest radiography during the study period; 1,546 children with radiographically proven CAAP (58% boys) and 441 control subjects (54% boys) were prospectively enrolled. Frequent snoring was reported in 18.6% vs 2.9% subjects with CAAP and control subjects, respectively (P < .001). The respective figures for subjects with CAAP and control subjects for restless sleep, nocturnal breathing problems, abnormal behavior, and chronic rhinorrhea were 21.6% vs 5.3%, 5% vs 1.4%, 6.4% vs 0.2%, and 12.9% vs 1.8%, (P < .001 for each). Fifty children (3.3%) with CAAP vs three control subjects (0.7%) underwent adenoidectomy (P < .001). PSG diagnosis of obstructive sleep apnea had been established previously in 79 patients (5%) with CAAP vs six (1.3%) of the control subjects (OR, 3.7 [95% CI, 1.6-10.0]; P < .001), with higher severity in patients with CAAP than in control subjects.
Conclusions:
SDB is common in children with CAAP and is possibly a predisposing risk factor for CAAP in children < 5 years old. We recommend considering SDB in young children who are given a diagnosis of CAAP.
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