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Related Experiment Video

Updated: May 27, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

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Phylogenomic analysis of polyketide synthase-encoding genes in Trichoderma.

Scott E Baker¹, Giancarlo Perrone², Nathan M Richardson³

¹Chemical and Biological Process Development Group, Pacific Northwest National Laboratory, Richland, WA, USA.

Microbiology (Reading, England)

|November 19, 2011

Summary

This study explores polyketide synthases (PKSs) in Trichoderma fungi, known for biocontrol. The research provides a foundation for understanding these enzymes and their role in fungal secondary metabolism.

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Area of Science:

Mycology
Biochemistry
Genomics

Background:

Trichoderma species are vital ascomycete fungi with significant biocontrol applications.
Their mycoparasitic and plant defense-inducing traits are well-established.
Polyketide synthases (PKSs) are key enzymes in fungal secondary metabolism but are less studied in Trichoderma compared to other enzymes.

Purpose of the Study:

To conduct a phylogenomic analysis of the polyketide synthase (PKS) gene repertoire in Trichoderma.
To establish a foundational understanding of PKS diversity within the Trichoderma genus.
To facilitate future research on PKSs and their role in fungal secondary metabolite production.

Main Methods:

Phylogenomic analysis of PKS genes.
Genome-wide identification and characterization of PKSs in selected Trichoderma species.

Main Results:

Identification and cataloging of the PKS repertoire across Trichoderma reesei, Trichoderma atroviride, and Trichoderma virens.
Comparative analysis providing insights into PKS evolution and diversity within the genus.

Conclusions:

The study establishes a comprehensive genomic basis for PKS research in Trichoderma.
This work is crucial for future investigations into the function and application of PKSs in Trichoderma biocontrol agents and other filamentous fungi.