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Updated: May 27, 2026
09:50
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Flavonoids: A versatile source of anticancer drugs.
Maheep K Chahar1, Neelu Sharma, Mahabeer P Dobhal
1Department of Chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India.
Pharmacognosy Reviews
|November 19, 2011
Summary
Flavonoids show significant anticancer effects in chemoprevention and chemotherapy by influencing cell pathways. This review details their molecular mechanisms against various cancers, including mammary and prostate cancer.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Dietary components, specifically flavonoids, are increasingly studied for their molecular interactions affecting cellular fate.
- Compelling evidence from diverse research supports the role of flavonoids in cancer chemoprevention and chemotherapy.
Purpose of the Study:
- To review the anticancer activities of flavonoids.
- To elucidate the molecular mechanisms underlying flavonoid action in cancer.
- To highlight advanced flavonoid derivatives for cancer treatment.
Main Methods:
- Literature review of laboratory studies, epidemiologic investigations, and human clinical trials.
- Analysis of molecular mechanisms including gene-enzyme interactions.
- Focus on specific cancers like mammary and prostate cancer.
Main Results:
- Flavonoids exhibit anticancer properties through multiple mechanisms.
- Identified mechanisms include carcinogen inactivation, antiproliferation, cell cycle arrest, apoptosis induction, angiogenesis inhibition, antioxidation, and multidrug resistance reversal.
- Flavonoids interact with various genes and enzymes in cancer prevention.
Conclusions:
- Flavonoids are potent agents in cancer chemoprevention and chemotherapy.
- Their diverse molecular mechanisms offer broad anticancer potential.
- Novel flavonoid derivatives show promise for enhanced cancer therapy.
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