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Updated: May 27, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Hypertension in Cardiovascular and Kidney Disease
Joshua Botdorf1, Kunal Chaudhary, Adam Whaley-Connell
1Division of Nephrology and Hypertension, Harry S. Truman VA Medical Center, University of Missouri-Columbia School of Medicine, Columbia, Mo., USA.
Insights
Hypertension and chronic kidney disease (CKD) management are linked. Controlling high blood pressure helps reduce cardiovascular risk and slow CKD progression, with strategies varying by kidney function level.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Background:
- The relationship between hypertension and chronic kidney disease (CKD) is bidirectional.
- Hypertension prevalence increases as kidney function declines.
- Cardiovascular disease is a major complication in CKD patients.
Purpose of the Study:
- To review evidence on hypertension management in CKD patients.
- To examine the impact of hypertension management on CKD progression.
- To discuss hypertension as a modifiable risk factor for cardiovascular disease in CKD.
Main Methods:
- Literature review of existing studies and clinical guidelines.
- Analysis of evidence for different hypertension management strategies.
- Examination of the effect of blood pressure control on CKD outcomes.
Main Results:
- Hypertension management strategies for cardiovascular risk reduction also benefit CKD progression.
- Specific management approaches for hypertension differ based on the level of kidney function.
- Effective blood pressure control is crucial for mitigating cardiovascular risks in CKD.
Conclusions:
- Managing hypertension is essential for both cardiovascular health and slowing CKD progression.
- Tailored hypertension management strategies are necessary according to CKD stage.
- Further research is needed to optimize hypertension treatment in CKD.
Abstract:
The relationship between hypertension and chronic kidney disease (CKD) is bidirectional in nature and, generally, management strategies for cardiovascular risk reduction also attenuate progression of CKD. Prevalent hypertension increases with diminishing kidney function, and the management strategy changes with level of kidney function. In this review, we will examine the evidence for management of hypertension, as a modifiable risk factor for cardiovascular disease in CKD, and the impact of this management on progression of CKD.
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