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09:38
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
Varicella zoster virus and relapsing remitting multiple sclerosis.
1Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City 14269, Mexico.
Multiple Sclerosis International
|November 19, 2011
Summary
Varicella zoster virus (VZV) may trigger multiple sclerosis (MS). Studies show VZV DNA in MS patients during relapses, suggesting a link between this herpes virus and MS development.
Area of Science:
- Neuroimmunology
- Virology
Background:
- Multiple sclerosis (MS) is an immune-mediated neurological disorder.
- The specific triggers for MS remain largely unknown.
- Herpes family viruses are investigated as potential causative agents.
Purpose of the Study:
- To review evidence supporting an association between varicella zoster virus (VZV) and multiple sclerosis (MS).
Main Methods:
- Review of epidemiological studies correlating VZV infections with MS incidence.
- Analysis of laboratory investigations detecting VZV DNA in MS patients.
Main Results:
- Geographical studies show increased MS incidence in areas with high rates of varicella and zoster.
- VZV DNA detected in leukocytes and cerebrospinal fluid during MS relapses, disappearing during remission.
- VZV exhibits neurotropism and latency, consistent with a role in MS etiology.
Conclusions:
- Epidemiological and laboratory findings suggest VZV may play a role in MS etiology.
- Conflicting results regarding viral gene products in brain tissue necessitate further research.
- The potential involvement of VZV in MS pathogenesis requires continued investigation.
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