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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Updated: May 27, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Trends in trauma transfusion.

Sanjay M Bhananker1, Ramesh Ramaiah

  • 1Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA.

International Journal of Critical Illness and Injury Science
|November 19, 2011
PubMed
Summary
This summary is machine-generated.

Severe trauma and blood loss cause many deaths. Early interventions for coagulopathy, hypothermia, and acidosis, alongside advanced transfusion strategies, are improving survival rates in trauma patients.

Keywords:
Coagulopathyhemorrhagemassive transfusionthromboelastometrytransfusiontrauma

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Integrated Compensatory Responses in a Human Model of Hemorrhage
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Last Updated: May 27, 2026

Microfluidics in Assessing Platelet Function
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Published on: November 8, 2024

Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

Area of Science:

  • Trauma and Emergency Medicine
  • Hemorrhagic Shock Management

Background:

  • Trauma is a leading cause of death in young adults, with acute blood loss a major contributor to early mortality.
  • The "lethal triad" of coagulopathy, hypothermia, and acidosis necessitates advanced resuscitation strategies.

Purpose of the Study:

  • To review recent advancements in managing severe trauma and acute blood loss.
  • To highlight emerging transfusion practices and interventions for trauma-induced coagulopathy.

Main Methods:

  • Review of clinical practices from military conflicts (Iraq and Afghanistan).
  • Analysis of retrospective and prospective studies on civilian transfusion practices.
  • Examination of emerging trends in trauma resuscitation and hemostasis monitoring.

Main Results:

  • Shift towards early correction of coagulopathy with high ratios of fresh frozen plasma and platelets to packed red blood cells (FFP:platelet:RBC).
  • Emphasis on preventing and correcting hypothermia and acidosis.
  • Increased use of point-of-care hemostasis monitoring (e.g., thromboelastometry) and specific agents like tranexamic acid.

Conclusions:

  • Military trauma management lessons offer valuable insights for civilian settings.
  • Further research is needed to validate military-derived strategies in civilian trauma centers.
  • Proactive identification and intervention for patients at risk of massive transfusion can reduce trauma-related morbidity and mortality.