Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Occupational contact dermatitis in blue-collar workers: results from a multicentre study from the Danish Contact Dermatitis Group (2003-2012).

Contact dermatitis·2014
Same author

Effectiveness of the Healthy Skin Clinic--a randomized clinical trial of nurse-led patient counselling in hand eczema.

Contact dermatitis·2014
Same author

Occupational contact dermatitis in hairdressers: an analysis of patch test data from the Danish contact dermatitis group, 2002-2011.

Contact dermatitis·2013
Same author

[Cutaneous leishmaniasis].

Ugeskrift for laeger·2013
Same author

[Clinical database in contact allergy].

Ugeskrift for laeger·2012
Same author

Systemic allergic dermatitis presumably caused by formaldehyde derived from aspartame.

Contact dermatitis·2012
Same journal

Preliminary Validation of the Early Sacroiliitis Screening Tool (ESHST) for Identifying Hidradenitis Suppurativa Patients at High Risk of Spondyloarthritis.

International journal of dermatology·2026
Same journal

Increased Risk of Deep Vein Thrombosis and Pulmonary Embolism in Hidradenitis Suppurativa Patients With Down Syndrome: A Retrospective Cohort Study.

International journal of dermatology·2026
Same journal

Efficacy of Intralesional Bevacizumab Versus Intralesional Triamcinolone Acetonide Injection in the Treatment of Keloids: A Randomized Clinical Trial.

International journal of dermatology·2026
Same journal

Application Site Adverse Events of Topical Nonsteroidal Immunomodulators: A Post-Marketing Analysis of the FDA Adverse Event Reporting System.

International journal of dermatology·2026
Same journal

Follicular Disorders Associated With Pseudofolliculitis Barbae: A TriNetX Retrospective Cohort Study.

International journal of dermatology·2026
Same journal

mTOR-Responsive PIK3CA p.E542K-Harboring Sweat Gland Carcinoma With Neuroendocrine Differentiation.

International journal of dermatology·2026
See all related articles

Related Experiment Video

Updated: May 27, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Systemic contact dermatitis.

Niels K Veien1

  • 1Dermatology Clinic, Vesterbro 99, Aalborg, Denmark. veien@dadlnet.dk

International Journal of Dermatology
|November 22, 2011
PubMed
Summary
This summary is machine-generated.

Systemic contact dermatitis (SCD) is an inflammatory skin condition triggered by allergen exposure through various routes. Treatment focuses on hapten avoidance, with options like diet modification and chelation therapy for specific cases.

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Related Experiment Videos

Last Updated: May 27, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Area of Science:

  • Dermatology
  • Allergology
  • Immunology

Background:

  • Systemic contact dermatitis (SCD) is an inflammatory skin disease.
  • It occurs in individuals with contact allergies upon exposure to haptens via various routes (oral, transcutaneous, rectal, intravesical, intravenous, inhalation).
  • Common causes include drugs, metals (nickel, cobalt, gold, chromate), and aromatic substances (spices).

Purpose of the Study:

  • To summarize the causes, diagnosis, and management of systemic contact dermatitis.
  • To highlight treatment strategies including hapten avoidance, dietary modifications, chelation therapy, and hyposensitization.

Main Methods:

  • Review of existing literature on systemic contact dermatitis.
  • Analysis of common haptens and their routes of exposure.
  • Evaluation of therapeutic interventions for SCD.

Main Results:

  • Haptens can trigger SCD through multiple exposure routes.
  • Drugs and ubiquitous environmental allergens like metals and spices are frequent culprits.
  • Effective management relies on identifying and avoiding the causative hapten.

Conclusions:

  • Systemic contact dermatitis necessitates careful identification of the offending hapten.
  • Treatment options range from avoidance to specific therapies like diet modification, chelation, and hyposensitization.
  • Further research into hyposensitization may offer new therapeutic avenues for SCD.